Nelson became one of Locker's Lieutenants in the 'Lowestoffe' in 1777, and they remained lifelong friends. Locker's interest in art is reflected in his friendship with the marine painter, Dominic Serres, who also painted his portrait. As Lieutenant-Governor of Greenwich Hospital from 1793, he conceived the idea of a naval picture gallery in the Painted Hall. The plan was eventually put into effect by his son, Edward Hawke Locker, in 1823-1824. He was Governor of Greenwich Hospital when he died.
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